Regulatory T cells in allergic diseases

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• 作者：Magali Noval Rivas ; PhD^a ; Talal A. Chatila ; MD ; MSc^b ; ^c ; ^{talal.chatila@childrens.harvard.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Asthma ; food allergy ; regulatory T cells ; forkhead box P3 ; IL-4 ; TH2 cells
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：138
• 期：3
• 页码：639-652
• 全文大小：2838 K

文摘

The pathogenesis of allergic diseases entails an ineffective tolerogenic immune response to allergens. Regulatory T (Treg) cells play a key role in sustaining immune tolerance to allergens, yet mechanisms by which Treg cells fail to maintain tolerance in patients with allergic diseases are not well understood. We review current concepts and established mechanisms regarding how Treg cells regulate different components of allergen-triggered immune responses to promote and maintain tolerance. We will also discuss more recent advances that emphasize the “dual” functionality of Treg cells in patients with allergic diseases: how Treg cells are essential in promoting tolerance to allergens but also how a proallergic inflammatory environment can skew Treg cells toward a pathogenic phenotype that aggravates and perpetuates disease. These advances highlight opportunities for novel therapeutic strategies that aim to re-establish tolerance in patients with chronic allergic diseases by promoting Treg cell stability and function.