The activity of new aroxyalkyl derivatives of 2-methoxyphenylpiperazine was studied.
The compounds showed significant antidepressant-like activity.
The compounds interact with 5-HT1A, 5-HT2A, 5-HT3 and 5-HT7 receptors.
Compound 3 is a partial 5-HT1A receptors agonist displaying multiple activities.
5-HT1A receptors activation is crucial for compound 3 antidepressant-like activity.