Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats
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- 作者：Rená ; ta Krisztina Lakatosa ; b ; reni.lakatos@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Á ; rpá ; d Dobolyic ; d ; dobolyi.arpad@med.semmelweis-univ.hu" class="auth_mail" title="E-mail the corresponding author ; Mihail Ivilinov Todorovc ; e ; mtodorov@t-online.hu" class="auth_mail" title="E-mail the corresponding author ; Katalin A. Ké ; kesie ; f ; kakekesi@ttk.elte.hu" class="auth_mail" title="E-mail the corresponding author ; Gá ; bor Juhá ; sze ; g ; gjuhasz@dec001.geobio.elte.hu" class="auth_mail" title="E-mail the corresponding author ; Magdolna Alekszah ; aleksza.magdolna13@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Zsolt Ková ; csb ; zskovacs@ttk.nyme.hu" class="auth_mail" title="E-mail the corresponding author ; zsolt.kovacs@nyme.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：A1R ; adenosine A1 receptor ; A2AR ; adenosine A2A receptor ; Ado ; adenosine ; ADP ; Ado diphosphate ; AMP ; Ado monophosphate ; ATPA ; do triphosphate ; CNS ; central nervous system ; COX ; cyclooxygenase ; DMSO ; dimethyl sulfoxide ; EEG ; electroencephalogram ; FFT ; Fast Fourier Transform ; GABA ; gamma-aminobutyric acid ; GDP ; Guo diphosphate ; GMP ; Guo monophosphate ; Gn ; guanine ; GTP ; Guo triphosphate ; Guo ; guanosine ; IL-1β ; interleukin-1β ; IMP ; Ino monophosphate ; Ino ; inosine ; i.p. ; intraperitoneal ; LPS ; lipopol
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：172-181
- 全文大小：1755 K
文摘
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i.p. 50 mg/kg Guo decreased the number of spike-wave discharges (SWDs).
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i.p. 100 mg/kg Guo enhanced the number of SWDs in WAG/Rij rats.
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Effect of 100 mg/kg Guo was inhibited by theophylline, SCH 58261 and indomethacin.
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i.p. 100 mg/kg Guo may increase SWD number by means of adenosinergic system.