Bitriazolyl acyclonucleosides synthesized via Huisgen reaction using internal alkynes show antiviral activity against tobacco mosaic virus

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• 作者：Menghua Wang ; Ruizhi Zhu ; Zhijin Fan ; Yifeng Fu ; Liang Feng ; Jianhua Yao ; Alain Maggiani ; Yi Xia ; Fanqi Qu ; Ling Peng
• 关键词：Triazole nucleosides ; Bitriazolyl acyclonucleosides ; Bitriazolyl compounds ; Huisgen reaction ; Tobacco mosaic virus
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2011
• 出版时间：1 January 2011
• 年：2011
• 卷：21
• 期：1
• 页码：354-357
• 全文大小：409 K

文摘

A family of novel bitriazolyl acyclonucleosides were synthesized using a simple and convenient one-step synthetic procedure via the Huisgen reaction by addition of NaN₃ onto triazole nucleosides bearing internal alkynyl groups introduced at the 5-position of the triazole ring. Some of the compounds exhibited interesting antiviral activity against tobacco mosaic virus, demonstrating the importance of the bitriazolyl motif for the observed antiviral activity.