Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin
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- 作者：C. Connollya ; A. Magnusson-Lindb ; G. Lua ; P.K. Wagnera ; A.L. Southwella ; M.R. Haydena ; M. Bjö ; rkqvistb ; B.R. Leavitta ; bleavitt@cmmt.ubc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：ASO ; antisense oligonucleotide ; CSE ; control standard endotoxin ; FAAH ; fatty acid amide hydrolysis ; FRET ; Fö ; rster resonance energy transfer ; HD ; Huntington&rsquo ; s Disease ; INF-γ ; Interferon-γ ; LPS ; lipopolysaccharide ; MMP3 ; Matrix metalloprotease 3 ; MMPs ; Matrix metalloproteinases ; MSD ; Meso Scale Discovery ; MSN ; medium spiny neuron ; PET ; Positron emission tomography ; RAC ; raclopride ; RT ; room temperature ; TB ; terbium ; TIMPs ; tissue inhibitors of metalloproteinases
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：14 June 2016
- 年：2016
- 卷：325
- 期：Complete
- 页码：74-88
- 全文大小：1821 K
文摘
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Increased secretion of cytokines from microglia containing mutant huntingtin.
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Decreasing mutant huntingtin can ameliorate the mutant huntingtin over secretion phenotype.
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MMP3 an endogenous brain signal can activate microglia similar to pro-inflammatory stimuli, LPS.
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MMPs correlate with worsening of HD.