Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae)

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• 作者：Tsholofelo A. Mokoka ; Xolani.K. Peter ; Gerda Fouche ; Nivan Moodley ; Michael Adams ; Matthias Hamburger ; Marcel Kaiser ; Reto Brun ; Vinesh Maharaj ; Neil Koorbanally
• 关键词：VL ; Visceral leishmaniasis ; HIV ; human immunodeficiency virus ; SANBI ; South African National Biodiversity Institute ; HPLC ; high performance liquid chromatography ; DMSO ; dimethyl sulfoxide ; PBS ; phosphate buffer solution ; FBS ; foetal bovine serum ; PDA ; photo diode array ; NMR ; nuclear magnetic resonance ; MS ; mass spectrometry ; SI ; selectivity index ; DHT ; dihydrotestosterone ; AR ; androgen receptor ; SM ; simple monophasic
• 刊名：South African Journal of Botany
• 出版年：January, 2014
• 年：2014
• 卷：90
• 期：Complete
• 页码：93-95
• 全文大小：311 K

文摘

In South Africa, Salvia repens is used traditionally to treat sores, stomach ache and diarrhoea. The high performance liquid chromatography (HPLC)-based activity profiling of S. repens whole plant extract showed an active abietane diterpene, identified as 12-methoxycarnosic acid (1) which showed antiprotozoal activity against axenically grown Leishmania donovani amastigotes with an IC₅₀ of 0.75 渭M with marginal cytotoxicity against the L6-cells (IC₅₀, 17.3 渭M).