Sulfamic acid: an efficient, cost-effective and recyclable solid acid catalyst for the three-component synthesis of α-amino nitriles
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- 作者：Akbar Heydari ; Samad Khaksar ; Mehrdad Pourayoubi ; Ali Reza Mahjoub
- 关键词：α ; -Amino nitriles ; Sulfamic acid ; Trimethylsilyl cyanide ; Reusable
- 刊名：Tetrahedron Letters
- 出版年：2007
- 出版时间：4 June 2007
- 年：2007
- 卷：48
- 期：23
- 页码：4059-4060
- 全文大小：102 K
文摘
α-Amino nitriles are synthesized by the three-component coupling reaction of aldehydes, amines and trimethylsilyl cyanide using sulfamic acid as a heterogeneous solid acid catalyst, under solvent-free conditions in excellent yields. The catalyst was recovered by simple filtration and was recycled in subsequent reactions.