Keratinizing odontogenic cysts with a spectrum of verrucoid morphology: investigation of a potential role of human papillomavirus

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• 作者：Kalpesh Lalla ; BDS ; MSc(Dent) ; Farzana Mahomed ; BChD ; MDent ; ^{Farzana.mahomed@wits.ac.za" class="auth_mail" title="E-mail the corresponding author} ; Shabnum Meer ; BChD ; MDent ; FCP(SA)Oral Path
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：122
• 期：5
• 页码：625-630
• 全文大小：1278 K

文摘

The role of human papillomavirus (HPV) in keratinizing odontogenic cysts (OC) has only rarely been studied. We describe the clinicopathologic findings in a series of OCs that had unusual keratinization patterns and were investigated for a possible HPV etiology.

Study Design

Tissue samples from 29 patients with keratinizing OCs were studied for light microscopic features suggestive of HPV infection and by an HPV DNA polymerase chain reaction assay.

Results

The mean age at presentation was 31.1 years; 79.3% of the OCs occurred in the mandible and 46.4% were associated with an impacted tooth. The phenotypic characteristics koilocytes, hypergranulosis, and a verrucous pattern of the cyst-lining epithelium were observed in 69%, 62.1%, and 17.2% of cases, respectively. These histomorphologic features did not, however, correlate with HPV infection.

Conclusions

HPV does not appear to play a role in keratinizing OCs and is not responsible for the wart-like histomorphologic features that may be seen in these lesions.