Soluble triggering receptor expressed on myeloid cells 1 and the diagnosis of sepsis

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• 作者：Mitra Barati ; Farshid Rahimi Bashar ; Reza Shahrami ; Mohammad Hossein Jarrah Zadeh ; Mahshid Talebi Taher ; Marzieh Nojomi
• 关键词：Soluble triggering receptor expressed on myeloid cells-1 ; Systemic inflammatory response syndrome ; C-reactive protein ; Sepsis
• 刊名：Journal of Critical Care
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：25
• 期：2
• 页码：362.e1-362.e6
• 全文大小：266 K

文摘

Purpose

Early diagnosis and assessment of the systemic inflammatory response to infection are difficult with usual markers (fever, leukocytosis, C-reactive protein [CRP]). Triggering receptor expressed on myeloid cells-1 (TREM-1) expression on phagocytes is up-regulated by microbial products. We studied the ability of soluble TREM-1 (sTREM-1) to identify patients with sepsis.

Materials and Methods

Plasma samples were obtained on intensive care unit admission from patients with systemic inflammatory response syndrome for sTREM-1 measurement.

Results

Soluble TREM-1, CRP concentrations and erythrocyte sedimentation rate (ESR) were higher in the sepsis group (n = 52) than in the non-infectious systemic inflammatory response syndrome group (n = 43; P = .00, .02, and .001, respectively). Soluble TREM-1, CRP concentrations, white blood cell count and ESR were higher in the sepsis group than in the non SIRS group (n = 37; P = .04, .00, .01, and .00, respectively).

In a receiver-operating characteristic curve analysis, ESR, CRP and sTREM-1 had an area under the curve larger than 0.65 (P = .00), in distinguishing between septic and non-infectious SIRS patients. CRP, ESR, sTREM-1 had a sensitivity of 60 % , 70 % and 70 % and a specificity of 60 % , 69 % and, 60 % respectively in diagnosing infection in SIRS.

Conclusion

C-reactive protein and ESR performed better than sTREM-1 and white blood cell count in diagnosing infection.