Effect of maternal supplementation with vitamin E on the concentration of α-tocopherol in colostrum

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• 作者：Larisse Rayanne Miranda de Melo^a ; Heleni Aires Clemente^a ; Dalila Fernandes Bezerra^a ; Raquel Costa Silva Dantas^a ; H&eacute ; ryka Myrna Maia Ramalho^b ; Roberto Dimenstein^a ; ^{rdimenstein@gmail.com}
• 关键词：Maternal supplementation ; Vitamin E ; Alpha-tocopherol ; Nutritional needs ; Newborn ; Human colostrum
• 刊名：Jornal de Pediatria
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：93
• 期：1
• 页码：40-46
• 全文大小：573 K
• 卷排序：93

文摘

To evaluate the effect of maternal supplementation with vitamin E on the concentration of α-tocopherol in colostrum and its supply to the newborn.MethodThis randomized clinical trial enrolled 99 healthy adult pregnant women; of these, 39 were assigned to the control group and 60 to the supplemented group. After an overnight fast, 5 mL of blood and 2 mL of colostrum were collected. After the first sampling (0 h milk), the supplemented group received 400 IU of supplementary vitamin E. Another 2 mL milk aliquot was collected in both groups 24 h after supplementation (24 h milk). The samples were analyzed by high-performance liquid chromatography. The α-tocopherol content provided by colostrum was calculated by considering a daily intake of 396 mL of milk and comparing the resulting value to the recommended daily intake for infants aged 0–6 months (4 mg/day).ResultsThe initial mean concentration of α-tocopherol in colostrum was 1509.3 ± 793.7 μg/dL in the control group and 1452.9 ± 808.6 μg/dL in the supplemented group. After 24 h, the mean α-tocopherol concentration was 1650.6 ± 968.7 μg/dL in the control group (p > 0.05) and 2346.9 ± 1203.2 μg/dL in the supplemented group (p < 0.001), increasing the vitamin E supply to the newborn to 9.3 mg/day. Initially, 18 women in the supplemented group provided colostrum α-tocopherol contents below 4 mg/day; after supplementation only six continued to provide less than the recommended amount.ConclusionMaternal vitamin E supplementation increases the supply of the vitamin to the infant by providing more than twice the Recommended Daily Intake.