Intra-Articular Blockade of P2X7 Receptor Reduces the Articular Hyperalgesia and Inflammation in the Knee Joint Synovitis Especially in Female Rats

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• 作者：Juliana Maia Teixeira ; Elayne Vieira Dias ; Carlos Am&iacute ; lcar Parada ; Cl&aacute ; udia Herrera Tambeli ; ^{tambeli@unicamp.br}
• 关键词：P2X7 receptor ; articular hyperalgesia ; synovitis ; sex difference ; proinflammatory cytokine ; neutrophil migration
• 刊名：The Journal of Pain
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：18
• 期：2
• 页码：132-143
• 全文大小：1323 K
• 卷排序：18

文摘

P2X7 receptor blockade reduced the hyperalgesia and inflammation in rats' knee joint. Female rats were more responsive than male rats to the P2X7 receptor blockade effects. P2X7 receptor blockers might be effective on articular inflammatory conditions.