Electrochemical S4O62− degradation was studied with biological and abiotic anodes. Bioelectrochemical current production from S4O62− started at 0.3 V vs. Ag/AgCl. Electrochemical current production from S4O62− started at 0.5 V vs. Ag/AgCl. S4O62− degradation rate was over three times higher in bioelectrochemical system. Reaction products from S4O62− differed between biological and abiotic anodes.