伪-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion

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• 作者：Jianjun Lei^a ; ¹ ; Xiongwei Huo^b ; ¹ ; Wanxing Duan^a ; Qinhong Xu^a ; Rong Li^a ; Jiguang Ma^c ; Xuqi Li^b ; Liang Han^a ; Wei Li^a ; Hao Sun^a ; ^{sunhaoxjyf@126.com" class="auth_mail} ; Erxi Wu^d ; Qingyong Ma^a ; ^{qyma56@mail.xjtu.edu.cn" class="auth_mail}
• 关键词：伪-Mangostin ; PSC ; Hypoxia ; ROS ; Pancreatic cancer
• 刊名：Cancer Letters
• 出版年：28 May, 2014
• 年：2014
• 卷：347
• 期：1
• 页码：129-138
• 全文大小：2577 K

文摘

Recent advances indicating a key role of microenvironment for tumor progression, we investigated the role of PSCs and hypoxia in pancreatic cancer aggressiveness, and examined the potential protective effect of 伪-mangostin on hypoxia-driven pancreatic cancer progression. Our data indicate that hypoxic PSCs exploit their oxidative stress due to hypoxia to secrete soluble factors favouring pancreatic cancer invasion. 伪-Mangostin suppresses hypoxia-induced PSC activation and pancreatic cancer cell invasion through the inhibition of HIF-1伪 stabilization and GLI1 expression. Increased generation of hypoxic ROS is responsible for HIF-1伪 stabilization and GLI1 upregulation. Therefore, 伪-mangostin may be beneficial in preventing hypoxia-induced pancreatic cancer progression.