A Magic Spot in Genome Maintenance

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• 作者：Aviram Rasouly¹ ; ² ; ³ ; Bibhusita Pani¹ ; ³ ; Evgeny Nudler¹ ; ² ; ^{evgeny.nudler@nyumc.org}
• 关键词：DNA repair ; transcription elongation ; backtracking ; ppGpp ; mutation rate
• 刊名：Trends in Genetics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：1
• 页码：58-67
• 全文大小：2163 K
• 卷排序：33

文摘

Nucleotide excision repair (NER) is the key DNA repair system that eliminates the majority of DNA helix-distorting lesions. RNA polymerase (RNAP) expedites the recognition of DNA damage by NER components via transcription-coupled DNA repair (TCR). In bacteria, a modified nucleotide ppGpp (‘magic spot’) is a pleiotropic second messenger that mediates the response to nutrient deficiencies by altering the initiation properties of RNAP. In this review, we discuss newly elucidated roles of guanosine 5′-diphosphate 3′-diphosphate (ppGpp) in transcription elongation that couple this alarmone to DNA damage repair and maintenance.