Increased aquaporin 1 and 5 membrane expression in the lens epithelium of cataract patients
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- 作者：Olatz Barandika ; BSca ; 1 ; Maitane Ezquerra-Inchausti ; BSca ; 1 ; Ander Anasagasti ; BPharma ; Ainara Vallejo-Illarramendi ; PhDa ; Irantzu Llarenab ; Lucia Bascaran ; MDc ; Txomin Alberdi ; MDc ; Giacomo De Benedetti ; MDd ; Javier Mendicute ; MD ; PhDc ; Javier Ruiz-Ederra ; PhDa ; javiruizederra@yahoo.es" class="auth_mail" title="E-mail the corresponding author ; javier.ruizederra@osakidetza.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：AQP ; aquaporin ; HLECs ; human lens epithelial cells
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：1862
- 期：10
- 页码：2015-2021
- 全文大小：1236 K
文摘
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This is the first comparative analysis of AQPs in cataracts human lens epithelium.
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A ~ 2-fold increase in AQP1 protein expression was found in cataract HLECs.
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Increased membrane AQP5 protein expression was found in cataract HLECs.
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This is likely a compensatory mechanism to increase water permeability in the lens.