N-Acetyl-cysteine modulates inducible nitric oxide synthase gene expression in human hepatocytes
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- 作者：Majano ; Pedro Lorenzo ; Medina ; Jesú ; s ; Zubí ; a ; Itxaso ; Sunyer ; Lourdes ; Lara-Pezzi ; Enrique ; et. al.
- 关键词：N-acetyl-cysteine ; Inducible nitric oxide synthase ; Nitric oxide ; Cytokines ; Nuclear factor κ ; B ; Hepatocytes
- 刊名：Journal of Hepatology
- 出版年：2004
- 出版时间：April, 2004
- 年：2004
- 卷：40
- 期：4
- 页码：632-637
- 全文大小：422 K
文摘
A major role has been described for inducible nitric oxide (NO) synthase in several chronic inflammatory liver diseases. N-Acetyl-cysteine (NAC) is a sulfhydryl donor molecule with antioxidant and antiinflammatory effects. It attenuates NO generation following lipopolysaccharide injection in rats. Our goal was to study the effect of NAC on NO synthase induction in hepatocytes in response to proinflammatory cytokines.