S-Adenosylmethionine modulates inducible nitric oxide synthase gene expression in rat liver and isolated hepatocytes

详细信息    查看全文

• 作者：Majano ; Pedro Lorenzo ; Garcí ; a-Monzó ; n ; Carmelo ; Garcí ; a-Trevijano ; Elena Ruiz ; et. al.
• 关键词：S-Adenosylmethionine ; Inducible nitric oxide synthase ; Endotoxemia ; Cytokines ; Liver ; Gene expression
• 刊名：Journal of Hepatology
• 出版年：2001
• 出版时间：December, 2001
• 年：2001
• 卷：35
• 期：6
• 页码：692-699
• 全文大小：244 K

文摘

Background/Aims: Hepatocellular availability of S-adenosylmethionine, the principal biological methyl donor, is compromised in situations of liver damage. S-Adenosylmethionine administration alleviates experimental liver injury and increases survival in cirrhotic patients. The mechanisms behind these beneficial effects of S-adenosylmethionine are not completely known. An inflammatory component is common to many of the pathological conditions in which S-adenosylmethionine grants protection to the liver. This notion led us to study the effect of S-adenosylmethionine administration on hepatic nitric oxide synthase-2 induction in response to bacterial lipopolysaccharide and proinflammatory cytokines.