- 作者：Yasushi Funaki ; momomaru@aichi-med-u.ac.jp ; Kentaro Tokudome ; Shinya Izawa ; Yasuhiro Tamura ; Yoshihiro Kondo ; Akihito Iida ; Mari Mizuno ; Naotaka Ogasawara ; Makoto Sasaki ; Kunio Kasugai
- 关键词：gastric pH ; gastroesophageal reflux disease ; nocturnal gastric acid breakthrough ; on demand ; proton pump inhibitor
- 刊名：Journal of the Chinese Medical Association
- 出版年：2013
- 出版时间：March, 2013
- 年：2013
- 卷：76
- 期：3
- 页码：131-134
- 全文大小：278 K
Background
It is known that the pharmacokinetic profile of proton pump inhibitors (PPIs) after postprandial administration may differ among PPIs. The purpose of this study was to compare the inhibitory effects of gastric acid secretion by PPIs administered after a meal, based on a 24-hour intragastric pH monitoring.Methods
Ten healthy men who provided written informed consent participated in the study. They were given a 20-mg omeprazole tablet and a 30-mg lansoprazole orally dispersing tablet in a two-way crossover manner. At baseline, the anti-HP-IgG antibody levels in blood and the pepsinogen (PG) I/II ratio were measured. Participants were given a standardized meal and 200?mL of water at 9:30 am, 13:30 pm, and 18.30 pm. Participants took the PPI after breakfast.
Results
Two of the ten participants tested positive for Helicobacter pylori infection. The PG I/II ratio indicated negative gastric atrophy in all the participants. The percentage 24-hour intragastric pH?>?4 holding times (median, range) with omeprazole and lansoprazole were 29.3, 19.3-50.0 % and 27.8, 13.0-42.3 % , respectively, which shows that with the administration of omeprazole, the pH was maintained at >4 for a longer period (p?<?0.05). Each median intragastric pH value per hour at 3, 17, and 18 hours after a dose of omeprazole was significantly higher than that of lansoprazole (p?<?0.05).
Conclusion
Compared with lansoprazole, a single postprandial dose of omeprazole showed a more rapid and sustained acid-inhibitory effect.