Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats

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• 作者：Bassem Sadekp>ap>p> ; p>p>bassem.sadek@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding authorp> ; Ali Saadp>ap> ; Dhanasekaran Subramanianp>ap> ; Mohamed Shafiullahp>ap> ; Dorota Łażewskap>bp> ; Katarzyna Kieć-Kononowiczcp>bp>
• 关键词：Histamine H3 receptor ; Epilepsy ; Anticonvulsant ; Learning ; Memory ; Passive avoidance test ; Pyrilamine ; R-(α)-methyl-histamine
• 刊名：Neuropharmacology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：106
• 期：Complete
• 页码：46-55
• 全文大小：1297 K

文摘

<dl class="listitem" id="list_ulist0010"><dt class="label">•dt><dd><p id="p0010">The effects of the H3R antagonist DL77 in different epilepsy and memory models were tested.p>dd><dt class="label">•dt><dd><p id="p0015">Acute DL77 administration provided anticonvulsant and memory-enhancing effects.p>dd><dt class="label">•dt><dd><p id="p0020">The results shed light on the potential therapeutic importance of H3Rs in epilepsy and memory.p>dd>dl>