Joint acute and endocrine disruptive toxicities of malathion, cypermethrin and prochloraz to embryo-larval zebrafish, Danio rerio
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- 作者：Dongmei Guo<sup>asup> ; Yanhua Wang<sup>bsup> ; Yongzhong Qian<sup>asup><sup> ; sup><sup>qyzcaas@aliyun.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Chen Chen<sup>asup> ; Bining Jiao<sup>csup> ; Leiming Cai<sup>bsup> ; Qiang Wang<sup>bsup><sup> ; sup><sup>Qiangwang2003@sina.com" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Combined toxicity ; Zebrafish ; Hypothalamic-pituitary-gonadal axis ; Estrogen ; Gene expression
- 刊名：Chemosphere
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：166
- 期：Complete
- 页码：63-71
- 全文大小：1514 K
文摘
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According to 96 h-LC<sub>50sub> values, the order of toxicity was as follows: CPM > PRO > MAL.
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Binary mixture of MAL + CPM displayed a synergistic effect on the acute toxicity to zebrafish larvae, and MAL + PRO showed an antagonistic effect.
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Transcription of many key genes involved in the HPG axis was a significantly altered after exposure to MAL + CPM and MAL + PRO.