Proteomics approach to examine the cardiotoxic effects of Nemopilema nomurai Jellyfish venom
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- 作者：Indu Choudharya ; Hyunkyoung Leea ; Min-Jung Pyoa ; Yunwi Heoa ; Seong Kyeong Baea ; Young Chul Kwona ; Won Duk Yoonb ; Changkeun Kanga ; c ; Euikyung Kima ; d ; ekim@gnu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：2DE ; Jellyfish ; Nemopilema nomurai ; Venom ; Protein ; MALDI-TOF/MS
- 刊名：Journal of Proteomics
- 出版年：2015
- 出版时间：14 October 2015
- 年：2015
- 卷：128
- 期：Complete
- 页码：123-131
- 全文大小：951 K
文摘
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We examined the cardiac toxicity of N. nomurai venom (NnV) at the proteome level.
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We treated H9c2 cells with NnV for 6 h and 12 h, along with control.
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2DE and MALDI-TOF/MS analysis resulted in 34 differentially expressed proteins.
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NnV targeted well known proteins involved in cardiac dysfunction or maintenance.
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These results clarify the underlying mechanism of cardiotoxicity by NnV.