Detection of ethanolamine altering in fetuses of pregnancy-associated hypertensive mice treated with vasodepressors by using UPLC and MALDI-TOF/MS
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- 作者：Koichiro Kakoa ; b ; Ayumi Nakamurab ; Yusuke Nagashimab ; Junji Ishidaa ; b ; c ; Akiyoshi Fukamizua ; b ; c ; akif@tara.tsukuba.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amines ; Ethanolamine ; Pregnancy-associated hypertension ; Anti-hypertensive drugs ; UPLC ; MALDI-TOF/MS
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：1006
- 期：Complete
- 页码：93-98
- 全文大小：1212 K
文摘
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6-Aminoquinoline carbamyl (AQC)-tag was used as a screening probe to label the amine.
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A combination of UPLC and MALDI-TOF/MS was advantageous to identifying tagged amines.
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Applying naphthylethyl column to estimate purified AQC-tagged amines.
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Ethanolamine was characterized as a hypotensor-responsive amine in pregnancy-associated hypertensive mice.