Glycogenomics, glycomics, and glycoinformatics will help in accelerating the understanding of the role that glycans play in protein therapeutics and diseases.
Recent advancements in glycogenomics, glycomics, glycoproteomics, and glycoinformatics tools to support analysis of glycan experimental measurements and the unique challenges due to interrogation and assimilation of disparate high-throughput glycosylation data sets are summarized in this report.
The era of advanced glycomics can enable discovery of novel glycoproteins and/or glycan biomarkers for diseases and also establish an understanding of the glycosylation behavior of therapeutics based on the glycogenome of the Chinese hamster ovary production host.
Novel methodologies can facilitate the integration of glycan measurements together with other ‘omics data sets that can lead to a better understanding of glycosylation as a complex cellular process.