- 作者：Diego Garc¨ªa-Compe¨¢n ; Joel O. J¨¢quez-Quintana ; Jos¨¦ A. Gonz¨¢lez-Gonz¨¢lez ; Fern ; o J. Lavalle-Gonz¨¢lez ; Jes¨²s Z. Villarreal-P¨¦rez ; Hector J. Maldonado-Garza
- 关键词：Diabetes mellitus ; Cirrosis hepá ; tica ; Curva de tolerancia oral a la glucosa ; Mortalidad
- 刊名：Gastroenterolog¨ªa y Hepatolog¨ªa
- 出版年：2013
- 出版时间：August-September, 2013
- 年：2013
- 卷：36
- 期：7
- 页码：473-482
- 全文大小：1108 K
The prevalence of overt diabetes mellitus (DM) in liver cirrhosis is about 30 % . However, DM or impaired glucose tolerance can be observed in 90 % after an oral glucose tolerance test in patients with normal fasting plasma glucose. Type 2 DM may produce cirrhosis, whereas DM may be a complication of cirrhosis. The latter is known as ?hepatogenous diabetes?. Overt and subclinical DM is associated with liver complications and death in cirrhotic patients. Treating diabetes is difficult in cirrhotic patients because of the metabolic impairments due to liver disease and because the most appropriate pharmacologic treatment has not been defined. It is also unknown if glycemic control with hypoglycemic agents has any impact on the course of the liver disease.