Sex differences in the effect of acute peripheral IL-1β administration on the brain and serum BDNF and VEGF expression in rats

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• 作者：Ewa Obuchowicz^a ; ^{eobuchowicz@sum.edu.pl} ; Marta Nowacka^a ; ^b ; ^c ; Monika Paul-Samojedny^d ; Anna M. Bielecka-Wajdman^a ; Andrzej Małecki^b
• 关键词：BDNF ; VEGF ; IL-1β ; Male and female rats
• 刊名：Cytokine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：90
• 期：Complete
• 页码：6-13
• 全文大小：894 K
• 卷排序：90

文摘

In females, after IL-1β injection serum IL-1β levels were higher than in males. In females, IL-1β enhanced the pituitary VEGF mRNA and serum VEGF and BDNF levels. In males IL-1β reduced BDNF mRNA in the brain structures except for the pituitary. In males, IL-1β decreased VEGF mRNA in the amygdala. Sex associated differences concerning BDNF and VEGF were observed in control rats.