Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia
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- 作者：Patrick Ejlerskov1 ; Jeanette Gö ; ransdotter Hultberg1 ; JunYang Wang1 ; Robert Carlsson1 ; Malene Ambjø ; rn1 ; Martin Kuss1 ; Yawei Liu1 ; Giovanna Porcu1 ; Kateryna Kolkova1 ; Carsten Friis Rundsten1 ; Karsten Ruscher2 ; Bente Pakkenberg3 ; Tobias Goldmann4 ; Desiree Loreth5 ; Marco Prinz4 ; 6 ; David C. Rubinsztein7 ; Shohreh Issazadeh-Navikas1 ; shohreh.issazadeh@bric.ku.dk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2015
- 出版时间：8 October 2015
- 年：2015
- 卷：163
- 期：2
- 页码：324-339
- 全文大小：9471 K
文摘
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Lack of neuronal IFN-β-IFNAR signaling causes brain Lewy body accumulation
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IFN-β deficiency causes late-stage autophagy block and thereby α-synuclein aggregation
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IFN-β promotes neuronal autophagy and α-synuclein clearance
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Ifnb gene therapy prevents dopaminergic neuron loss in a familial PD model