The social honey bee in biomedical research: realities and expectations

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• 作者：Ryszard Maleszka ^{ryszard.maleszka@anu.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Drug Discovery Today: Disease Models
• 出版年：2014
• 出版时间：Summer 2014
• 年：2014
• 卷：12
• 期：Complete
• 页码：7-13
• 全文大小：324 K

文摘

The social honey bee, Apis mellifera, is an organism of great value for behavioural, ecological and evolutionary studies. It is also an important agricultural insect and a source of allergies. In recent years its usefulness for research communities has been significantly expanded as a result of progress in genomics and epigenomics. While the bee is not to be misjudged as a model for a specific human disease, it complements other invertebrate models in areas of DNA methylation, metaboloepigenetics and is a source of medically and epigenetically active compounds. This article outlines the anticipated benefits flowing from the epigenome-inspired projects in honey bees and draws attention to the most promising avenues that are likely to strengthen the value of this organism in biomedical research.