4-T fMRI of the motor and sensory cortices in patients with polymicrogyria and epilepsy

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• 作者：J.G. Burneo^a ; ^{jburneo2@uwo.ca" class="auth_mail} ; R. Bartha^b ; J. Gati^b ; A. Parrent^a ; D.A. Steven^a
• 关键词：Epilepsy ; Polymicrogyria ; Functional MRI ; Reorganization
• 刊名：Clinical Neurology and Neurosurgery
• 出版年：July 2014
• 年：2014
• 卷：122
• 期：Complete
• 页码：29-33
• 全文大小：1211 K

文摘

Malformations of cortical development (MCD) are an increasingly recognized cause of medically intractable epilepsy. We assessed the role of fMRI in evaluating the motor and somatosensory cortices, as well as if there is possible reorganization of these vital areas in patients with polymicrogyria.

Methods

We included 2 patients with polymicrogyria and epilepsy. Somatosensory and motor cortices were assessed with a 4 T fMRI. These findings were compared with direct cortical stimulation.

Results

Localization of the sensorimotor cortices was adequately identified by fMRI. These vital areas did not reorganize outside the malformation of cortical development.

Conclusion

fMRI is a tool that can allow identification of these vital areas of the brain in a non-invasive manner.

Practice implications

Adequate localization of the sensorimotor cortices is important for optimal patient selection, surgical strategy, and to determine the maximal extent of the resection. The clinical implications for such understanding are not limited to it; these findings should help researchers understand more of the neurobiology of MCDs and even possibly clues to the mechanisms of epileptogenesis associated with such malformations.