Cardiopulmonary Exercise Testing in Heart Failure

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• 作者：Rajeev Malhotra ; MD^a ; Kristian Bakken ; NP^b ; Emilia D&rsquo ; Elia ; MD ; PhD^c ; ^d ; Gregory D. Lewis ; MD^a ; ^b ; ^{glewis@partners.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：cardiopulmonary exercise testing ; exercise physiology ; heart failure ; oxygen uptake ; ventilatory efficiency
• 刊名：JACC: Heart Failure
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：4
• 期：8
• 页码：607-616
• 全文大小：1428 K

文摘

Exercise intolerance, indicated by dyspnea and fatigue during exertion, is a cardinal manifestation of heart failure (HF). Cardiopulmonary exercise testing (CPET) precisely defines maximum exercise capacity through measurement of peak oxygen uptake (VO₂). Peak VO₂ values have a critical role in informing patient selection for advanced HF interventions such as heart transplantation and ventricular assist devices. Oxygen uptake and ventilatory patterns obtained during the submaximal portion of CPET are also valuable to recognize because of their ease of ascertainment during low-level exercise, relevance to ability to perform activities of daily living, independence from volitional effort, and strong relationship to prognosis in HF. The ability of peak VO₂ and other CPET variables to be measured reproducibly and to accurately reflect HF severity is increasingly recognized and endorsed by scientific statements. Integration of CPET with invasive hemodynamic monitoring and cardiac imaging during exercise provides comprehensive characterization of multisystem reserve capacity that can inform prognosis and the need for cardiac interventions. Here, we review both practical aspects of conducting CPETs in patients with HF for clinical and research purposes as well as interpretation of gas exchange patterns across the spectrum of preclinical HF to advanced HF.