Recent progress in the diagnosis and treatment of primary vitreoretinal lymphoma

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• 作者：Min Zhou^a ; Gezhi Xu^a ; ^b ; ^{xugezhi@sohu.com}
• 关键词：lymphoma ; primary ; retina ; vitreous
• 刊名：Taiwan Journal of Ophthalmology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：6
• 期：4
• 页码：170-176
• 全文大小：1138 K
• 卷排序：6

文摘

Primary vitreoretinal lymphoma (PVRL) was previously termed primary intraocular lymphoma. PVRL is a potentially fatal intraocular malignancy, and 65–90% of PVRL cases eventually involve the central nervous system (CNS). The incidence of PVRL has been rising in both immunocompromised and immunocompetent populations worldwide. PVRL frequently masquerades as chronic uveitis. Advanced auxiliary examinations, such as optical coherence tomography and fundus autofluorescence have been applied in the diagnosis of PVRL. Histology and immunohistochemistry in combination with molecular tests and interleukin-10 analysis have been demonstrated as reliable in diagnosing PVRL. Despite early initiation of treatment, mortality is high with PVRL associated with CNS involvement and relapses are common. The use of systemic chemotherapy has not been proven to prevent CNS involvement; however, local therapies including intravitreal injections of methotrexate and/or rituximab and low-dose radiotherapy to the eye, has shown to be extremely effective in controlling intraocular lymphoma with encouraging results.