Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis
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- 作者：Richard L. Gieseck III1 ; 2 ; Thirumalai R. Ramalingam1 ; Kevin M. Hart1 ; Kevin M. Vannella1 ; David A. Cantu1 ; Wei-Yu Lu3 ; Sofí ; a Ferreira-Gonzá ; lez3 ; Stuart J. Forbes3 ; Ludovic Vallier2 ; 4 ; Thomas A. Wynn1 ; twynn@niaid.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：45
- 期：1
- 页码：145-158
- 全文大小：9113 K
文摘
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Type 2 cell-mediated fibrosis and regeneration are independently regulated by IL-13
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Pathological fibrosis is driven by direct IL-13 signaling in PDGFRB+ fibroblasts
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IL-13 stimulates hepatobiliary progenitor cells and cholangiocytes to proliferate
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IL-13 regulates lipogenesis, bile acid synthesis, and biliary-dependent steatosis