Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters

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• 作者：Nicolá ; s Crisosto ; Ph.D. ; Bá ; rbara Echiburú ; Ph.D. ; Manuel Maliqueo ; Ph.D. ; Virginia Pé ; rez ; M.D. ; Amanda Ladró ; n de Guevara ; M.D. ; Jessica Preisler ; M.D. ; Fernando Sá ; nchez ; M.D. ; Teresa Sir-Petermann ; Ph.D. ; ^{tsir@med.uchile.cl}
• 关键词：Polycystic ovary syndrome ; antimü ; llerian hormone ; ovarian function ; metformin
• 刊名：Fertility and Sterility
• 出版年：2012
• 出版时间：January, 2012
• 年：2012
• 卷：97
• 期：1
• 页码：218-224
• 全文大小：157 K

文摘

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Objective

To evaluate the ovarian function during early infancy in daughters of women with polycystic ovary syndrome (PCOS) treated with metformin throughout pregnancy (PCOSd+M), as a means to reduce androgen and insulin levels, compared with daughters of nontreated PCOS women (PCOSd?M) and daughters of women who belong to a healthy comparison group (HCd).

Design

Descriptive and analytic study.

Setting

Unit of endocrinology and reproductive medicine.

Patient(s)

Fifteen PCOSd+M, 23 PCOSd?M, and 35 HCd were studied at 2-3 months of age.

Intervention(s)

A GnRH analogue test was performed with determinations of gonadotropins, sex steroids, SHBG, and anti-M¨¹llerian hormone (AMH).

Main Outcome Measure(s)

Differences in AMH levels between PCOSd+M, PCOSd?M and HCd.

Result(s)

AMH and peak E₂ concentrations were significantly higher in PCOSd?M compared with HCd, whereas PCOSd+M exhibited AMH concentrations and peak E₂ levels similar to those observed in HCd.

Conclusion(s)

The improvement of the altered endocrine-metabolic environment of PCOS mothers reduces AMH levels in their daughters, which might reflect a decrease in their follicular mass.