The sooner the better: innate immunity as a path toward the HIV cure
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- 作者：Jeffrey Tomalka1 ; 4 ; Khader Ghneim1 ; 4 ; Sanghamitra Bhattacharyya1 ; Malika Aid2 ; Dan H Barouch2 ; 3 ; Rafick Pierre Sekaly1 ; 5 ; Susan Pereira Ribeiro1 ; 5 ; sxp663@case.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Opinion in Virology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：19
- 期：Complete
- 页码：85-91
- 全文大小：755 K
文摘
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Virus dissemination occurs rapidly after mucosal SIV infection.
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Early innate host immune response after HIV/SIV infection dictates viral load at acute phase.
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Specific Interferon signatures are associated to viral dissemination.
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Inflammasome activation at early time-points inhibits intrinsic innate anti-viral responses and leads to virus dissemination and seeding.