Glucagon-like peptide-1 (7–36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium
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- 作者：Kavianipour ; Mohammad ; Ehlers ; Mario R. ; Malmberg ; Klas ; Ronquist ; Gunnar ; Ryden ; Lars ; Wikströ ; m ; Gerhard ; et. al.
- 关键词：Microdialysis ; Pig ; Myocardium ; Glucagon-like peptide-1 (7&ndash ; 36) amide ; Ischemia
- 刊名：Peptides
- 出版年：2003
- 出版时间：April, 2003
- 年：2003
- 卷：24
- 期：4
- 页码：569-578
- 全文大小：360 K
文摘
Glucagon-like peptide-1 (7–36) amide (GLP-1) has been studied as a treatment option in diabetic patients. We investigated the effect of recombinant GLP-1 infusion on hemodynamic parameters, myocardial metabolism, and infarct size during normoxic conditions as well as during ischemia and reperfusion using an open-chest porcine heart model. In the presence of rGLP-1, interstitial levels of pyruvate and lactate decreased during ischemia and reperfusion both in ischemic and non-ischemic tissue. Moreover, rGLP-1 infusion resulted in increased plasma insulin levels and decreased blood glucose levels. Neither hemodynamic variables nor the consequent infarct size were influenced by rGLP-1 infusion. We conclude that rGLP-1 altered myocardial glucose utilization during ischemia and reperfusion. It did not exert any untoward hemodynamic effects.