Among children in this developing area, symptoms of illness correlated with high-sensitivity C-reactive protein (hsCRP). hsCRP correlated positively with growth hormone (GH) and negatively with insulin-like growth factor (IGF)-1 and IGF-binding protein-3 (IGFBP-3). IGF-1 and IGFBP-3 correlated positively with height. These data are consistent with a model of inflammation-induced GH resistance.