文摘
Phosphate starvation (PS) promotes pathogenesis of B. anthracis (BA) within host. PhoP and PhoR of BA form a functional two component system, regulating PS response. PhoP is implicated in regulation of PS marker genes. H370 of PhoR and D10, D53 and M55 of PhoP are involved in PhoPR interaction. Exclusive in microbes, homology in pathogens, role in virulence & PS make PhoP as a good drug target.