Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells
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- 作者：Aaron Topol1 ; 10 ; Shijia Zhu2 ; 10 ; Brigham J. Hartley1 ; 3 ; Jane English4 ; Mads E. Hauberg5 ; 6 ; Ngoc Tran1 ; Chelsea Ann Rittenhouse1 ; Anthony Simone7 ; Douglas M. Ruderfer1 ; Jessica Johnson1 ; Ben Readhead2 ; Yoav Hadas1 ; Peter A. Gochman9 ; Ying-Chih Wang2 ; Hardik Shah2 ; Gerard Cagney8 ; Judith Rapoport9 ; Fred H. Gage7 ; Joel T. Dudley2 ; Pamela Sklar1 ; Manuel Mattheisen5 ; 6 ; David Cotter4 ; Gang Fang2 ; gang.fang@mssm.edu" class="auth_mail" title="E-mail the corresponding author ; Kristen J. Brennand1 ; 3 ; kristen.brennand@mssm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：human-induced pluripotent stem cell ; microRNA-9 ; neural progenitor cells ; schizophrenia
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：3 May 2016
- 年：2016
- 卷：15
- 期：5
- 页码：1024-1036
- 全文大小：3986 K
文摘
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miR-9 is highly expressed in NPCs and downregulated in a subset of SZ NPCs
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miR-9 expression level is strongly correlated with miR-9 regulatory activity
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Manipulation of miR-9 impacts neural migration
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miR-9 effects seem to be mediated by small changes in indirect miR-9 targets