Self-assembly of 6-O- and 6′-O-hexadecylsucroses mixture under aqueous conditions

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• 作者：Manami Kanemaru ; Shin-ya Kuwahara ; Kazuya Yamamoto ; Yoshiro Kaneko ; Jun-ichi Kadokawa
• 关键词：6-O- and 6′ ; -O-hexadecylsucroses ; Amphiphilic ; Self-assembly ; Nanoparticle ; Face-centered cubic ; Spherical micelle
• 刊名：Carbohydrate Research
• 出版年：2010
• 出版时间：10 December 2010
• 年：2010
• 卷：345
• 期：18
• 页码：2718-2722
• 全文大小：570 K

文摘

In this paper, we report the self-assembly of 6-O- and 6′-O-hexadecylsucroses mixture under aqueous conditions. The mixture was synthesized by a five-step sequence from sucrose. The SEM image of a sample prepared by drying a dispersion of the mixture in water showed nanoparticles with the diameter of 50 nm and aggregates that were formed by further assembly of them. The XRD measurement of the sample exhibited the diffraction pattern assignable to face-centered cubic (FCC) structure and the diameter of a sphere, which took part in the FCC structure, was calculated to be 5.1 nm. This value was relatively close to that observed in the DLS measurement of a dispersion of the mixture in water and estimated for a spherical micelle based on the molecular sizes of the two sucrose ethers. On the basis of the above findings, the following self-assembly process of the mixture under aqueous conditions was proposed. The mixture formed the spherical micelles with the diameter of 5–7 nm in water. The micelles regularly organized according to the FCC structure during the drying process from the aqueous dispersion to construct the nanoparticles with the diameter of 50 nm. Several numbers of the nanoparticles further assembled to form the aggregates.