The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery

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• 作者：Chitra D. Mandyam ^{cmandyam@scripps.edu} ; George F. Koob
• 关键词：Prefrontal cortex ; Gliogenesis ; Hippocampus ; Neurogenesis ; Addiction
• 刊名：Trends in Neurosciences
• 出版年：2012
• 出版时间：April, 2012
• 年：2012
• 卷：35
• 期：4
• 页码：250-260
• 全文大小：818 K

文摘

Addiction is a chronic relapsing disorder associated with compulsive drug taking, drug seeking and a loss of control in limiting intake, reflected in three stages of a recurrent cycle: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation (¡°craving?. This review discusses the role of adult-born neural and glial progenitors in drug seeking associated with the different stages of the addiction cycle. A review of the current literature suggests that the loss of newly born progenitors, particularly in hippocampal and cortical regions, plays a role in determining vulnerability to relapse in rodent models of drug addiction. The normalization of drug-impaired neurogenesis or gliogenesis may help reverse neuroplasticity during abstinence and, thus, may help reduce the vulnerability to relapse and aid recovery.