Low dose MK-801 reduces social investigation in mice

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• 作者：Hong Zou ; Chenghao Zhang ; Qinglian Xie ; Manfang Zhang ; Junwei Shi ; Meilei Jin ; Lei Yu
• 关键词：Social interaction ; Social recognition ; MK-801 ; Anogenital sniffing ; Mice
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2008
• 出版时间：October 2008
• 年：2008
• 卷：90
• 期：4
• 页码：753-757
• 全文大小：438 K

文摘

To characterize MK-801's effect on social behavior in mice, we examined adult male ICR mice for interaction with companion mice (juvenile male). Test mice were injected with either saline or MK-801 (0.1 mg/kg), and were tested 30 min later for their social behavior during a 5-min session. A second encounter took place 30 min later, with either a familiar companion mouse (the same as in the initial encounter) or a novel mouse. In saline controls, second encounter with a familiar companion mouse showed reduced social investigative behaviors (anogenital sniffing and staying together), indicating habituation toward a familiar mouse. Second encounter with a novel companion mouse did not show habituation in social investigative behaviors. Pretreatment with MK-801 reduced anogenital sniffing during the first encounter. At the second encounter, these mice displayed non-discriminative habituation of social investigative behaviors, with reduced anogenital sniffing and staying together, regardless of whether the companion mouse was a familiar or a novel one. These results indicate that MK-801 affected exploratory activities of mice, resulting in both reduced social investigative behaviors during first encounter with a companion mouse, and diminished discriminative capacities for a familiar vs. a novel companion mouse during subsequent encounter.