Pegylated and amphiphilic Chitosan coated manganese ferrite nanoparticles for pH-sensitive delivery of methotrexate: Synthesis and characterization

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• 作者：Z. Karimi^a ; S. Abbasi^b ; H. Shokrollahi^c ; ^{shokrollahi@sutech.ac.ir} ; Gh. Yousefi^b ; ^d ; ^{ghyousefi@sums.ac.ir} ; M. Fahham^c ; L. Karimi^e ; O. Firuzi^f
• 关键词：Manganese magnetic nanoparticles ; Co-precipitation ; PEG ; Chitosan ; Methotrexate ; pH- sensitive
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：504-511
• 全文大小：955 K
• 卷排序：71

文摘

Magnetic and structural studies of Fe1 − xMnxFe2O4 are investigated. Simple co-precipitation method involving less energy and low-cost is used. Superparamagnetic particles with high magnetization and low coercivity are obtained. The highest amount of MTX loading is related to S-Fe0.3Mn0.7Fe2O4-Cs-PEG-PA-MTX (1:1).