- 作者：Otavio Celeste Mangili ; Ana C. Moron Gagliardi ; Leonardo Celeste Mangili ; Carlos H. Mesquita ; Luiz A. Machado Cesar ; Akira Tanaka ; Ernst J. Schaefer ; Raul C. Maranh茫o ; Raul D. Santos
- 关键词：Simvastatin ; Ezetimibe ; Chylomicrons ; Triglyceride-rich lipoproteins ; Emulsions ; ApoB-48
- 刊名：Atherosclerosis
- 出版年：March, 2014
- 年：2014
- 卷：233
- 期：1
- 页码：319-325
- 全文大小：708 K
Objective
Reductions on the clearance from plasma of chylomicrons are associated with atherosclerosis. Statins improve the removal from plasma of chylomicrons in a dose dependent manner. There is controversy whether ezetimibe modifies the plasma clearance of chylomicrons. Effects of ezetimibe alone or in combination with simvastatin were compared with low and high dose of the latter, upon the kinetics of a chylomicron-like emulsion in coronary heart disease (CHD) patients.Methods
25 CHD patients were randomized for treatment with ezetimibe 10聽mg (group 1) or simvastatin 20聽mg (group 2) with progression to ezetimibe聽+聽simvastatin 10/20聽mg or simvastatin 80聽mg, respectively. Kinetic studies were performed at baseline and after each treatment period of 6 weeks. The fractional catabolic rates (FCR) of the emulsion labeled with 14C-CE and 3H-TG, that represent respectively chylomicron remnant and triglyceride removal, were calculated. Comparisons were made by ANOVA.
Results
The 14CE-FCR in group 1 were 0.005聽卤聽0.004, 0.011聽卤聽0.008 and 0.018聽卤聽0.005聽min鈭? and in group 2 were 0.004聽卤聽0.003, 0.011聽卤聽0.008 and 0.019聽卤聽0.007聽min鈭? respectively at baseline, after 6 and 12 weeks (p聽<聽0.05 vs. baseline, and 6 vs. 12 weeks). The 3H-TG-FCR in group 1 were 0.017聽卤聽0.011, 0.024聽卤聽0.011 and 0.042聽卤聽0.013聽min鈭? and in group 2 were 0.016聽卤聽0.009, 0.022聽卤聽0.009 and 0.037聽卤聽0.012聽min鈭? at baseline, after 6 and 12 weeks (p聽<聽0.05 vs. baseline, and 6 vs. 12 weeks). There were no differences between groups in time.
Conclusion
Both treatments increased similarly the removal from plasma of chylomicron and remnants in CHD patients.