Antihyperglycemic activity of phenylpropanoyl esters of catechol glycoside and its dimers from Dodecadenia grandiflora

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• 作者：Manmeet Kumar ; Preeti Rawat ; Neha Rahuja ; Arvind Kumar Srivastava ; Rakesh Maurya
• 关键词：Dodecadenia grandiflora ; Lauraceae ; Dodegranosides A– ; D ; Catechol ; Phenolic glycosides ; Antihyperglycemic activity ; STZ
• 刊名：Phytochemistry
• 出版年：2009
• 出版时间：July-August 2009
• 年：2009
• 卷：70
• 期：11-12
• 页码：1448-1455
• 全文大小：327 K

文摘

Bioactivity-guided separation of an antihyperglycemic extract from the leaves of Dodecadenia grandiflora afforded two phenylpropanoyl esters of catechol glycosides (1 and 4) and two lignane bis(catecol glycoside)esters (2 and 3). Their structures were established on the basis of extensive spectroscopic analysis (1D and 2D-NMR, MS). Compounds 2 and 3 are believed to be derived from dimerization via the two phenylpropanoid units of 1. Compounds 1–4 showed significant antihyperglycemic activity in streptozotocin-induced (STZ) diabetic rats, which is comparable to the standard drug metformin. Our results provide support to explain the use of D. grandiflora as antihyperglycemic agent by the traditional medical practitioners.