Fatal self administration of tramadol and propofol: A case report

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• 作者：Giulio Mannocchi ; Francesca Napoleoni ; Simona Napoletano ; Flaminia Pantano ; Mariangela Santoni ; Roberta Tittarelli ; Paolo Arbarello
• 关键词：Propofol ; Tramadol ; Toxicological ; Cardiac arrest ; GC&ndash ; MS
• 刊名：Journal of Forensic and Legal Medicine
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：20
• 期：6
• 页码：715-719
• 全文大小：768 K

文摘

We describe a case of unintentional intoxication due to tramadol and propofol self administration, occurred in a middle aged man, healthcare provider, deceased despite advanced medical assistance an hour later the onset of severe and increasing dyspnea. Toxicological analysis performed with gas chromatography-mass spectrometry in blood sample, evidenced a lethal tramadol concentration and therapeutic level of Propofol. Quantitative determination was also performed in other specimens such as bile, tissues (liver, spleen, kidney) and pubic hair, to assess chronic exposure. Toxicological results and autopsy findings, supported by clinical and hematochemical data, suggested a myocardial damage, associated with respiratory failure.