Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment
详细信息 查看全文
- 作者：Marijn Kuijpers1 ; 3 ; Dieudonné ; e van de Willige1 ; 3 ; Amé ; lie Freal1 ; Anaë ; l Chazeau1 ; Mariella A. Franker1 ; Jasper Hofenk1 ; Ricardo J. Cordeiro Rodrigues1 ; Lukas C. Kapitein1 ; Anna Akhmanova1 ; Dick Jaarsma2 ; Casper C. Hoogenraad1 ; c.hoogenraad@uu.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：axon initial segment ; neuron ; polarized transport ; cargo trafficking ; dynein ; NDE1 ; NDEL1 ; NudE ; Ankyrin-G
- 刊名：Neuron
- 出版年：2016
- 出版时间：3 February 2016
- 年：2016
- 卷：89
- 期：3
- 页码：461-471
- 全文大小：4445 K
文摘
- •
NDEL1 redistributes from the centrosome to the AIS during neurodevelopment
- •
Dynein regulator NDEL1 stably binds to Ankyrin-G at the AIS
- •
The motor protein dynein drives transport of somatodendritic cargo out of the AIS
- •
Accumulation of NDEL1 at the AIS is necessary for efficient local cargo reversal