Effect of dual delivery of antibiotics (vancomycin and cefazolin) and BMP-7 from chitosan microparticles on Staphylococcus epidermidis and pre-osteoblasts in vitro
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- 作者：Venkata P. Mantripragadaa ; Ambalangodage C. Jayasuriyaa ; b ; a.jayasuriya@utoledo.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cefazolin ; Vancomycin ; Staphylococcus epidermidis ; BMP-7 ; Chitosan microparticles ; Osteoblast
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：67
- 期：Complete
- 页码：409-417
- 全文大小：1281 K
文摘
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Bacterial infections involve the inflammatory destruction of joint and bone.
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Vancomycin and cefazolin half-life is limited to a few hours.
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Dual delivery of growth factor and antibiotic from the chitosan microparticles.
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Bioactivity of antibiotics released by the microparticles was protected.