Differential alterations in the ability of bovine neutrophils to generate extracellular and intracellular reactive oxygen species during the periparturient period

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• 作者：Manuela Rinaldi ; Paolo Moroni ; Max J. Paape ; Douglas D. Bannerman
• 关键词：Dairy cattle ; Mastitis ; Neutrophil ; Parturition ; Reactive oxygen species
• 刊名：The Veterinary Journal
• 出版年：2008
• 出版时间：November 2008
• 年：2008
• 卷：178
• 期：2
• 页码：208-213
• 全文大小：172 K

文摘

The periparturient period of a dairy cow is associated with increased incidence and/or severity of certain infectious diseases, including mastitis. It is believed that the heightened physiological demands of calving and initiation of milk production contribute to a state of immunosuppression during this period. Previous studies have indicated that neutrophil production of reactive oxygen species (ROS), which is a critical element of the host innate immune response to bacterial infection, is impaired in the 1–2 week period following calving. However, whether there is comprehensive inhibition of ROS production or selective inhibition of particular ROS remains unknown. The present study provides evidence that neutrophils isolated from cows (n = 20) after calving have an increased capacity to generate intracellular ROS and an impaired ability to release extracellular superoxide anion and hydrogen peroxide.