Neurexin, Neuroligin and Wishful Thinking coordinate synaptic cytoarchitecture and growth at neuromuscular junctions

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• 作者：Swati Banerjee ; ^{banerjees@uthscsa.edu} ; Anandakrishnan Venkatesan ; Manzoor A. Bhat
• 关键词：Neuromuscular junctions ; Synaptic growth ; Subsynaptic reticulum ; Neurexin ; Neuroligin 1 ; Wishful Thinking
• 刊名：Molecular and Cellular Neuroscience
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：78
• 期：Complete
• 页码：9-24
• 全文大小：3588 K
• 卷排序：78

文摘

Drosophila neurexin and neuroligin 1 display genetic and biochemical interactions. Dnrx and Dnlg1 are required for subcellular localization of Dlg at the synapse. Dnrx and Dnlg1 are required for the localization and stability of BMP receptor Wit. Dnrx and Dnlg1 regulate levels of BMP co-receptor Tkv and downstream effector Mad. Proper trans-synaptic adhesion is crucial for BMP receptor stability and signaling.