Impaired burrowing is the most prominent behavioral deficit of aging htau mice
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- 作者：Philippine Camilla Geiszler philippine.geiszler@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Matthew Richard Barron mbxmrb@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Marie-Christine Pardon ; marie.pardon@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：4R ; 4-repeat ; AD ; Alzheimer&rsquo ; s disease ; ANOVA ; analysis of variance ; MAP1A ; microtubule-associated protein 1A ; mtau&minus ; /&minus ; murine tau knockout ; NFTs ; neurofibrillary tangles ; RIPA ; radioimmunoassay precipitation
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：4 August 2016
- 年：2016
- 卷：329
- 期：Complete
- 页码：98-111
- 全文大小：1350 K
文摘
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htau mice exhibit robust deficits in food burrowing.
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Behavioral differences between htau and mtau−/− are age-dependent.
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Before 6 months of age, the htau phenotype is stronger than the mtau−/− phenotype.
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With aging, the htau phenotype is milder than the mtau−/− phenotype.