Differential roles of PKC isoforms (PKCs) and Ca²⁺ in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells

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• 作者：Shany Mugami^a ; Shani Kravchook^a ; Liat Rahamim-Ben Navi^a ; Rony Seger^b ; ¹ ; Zvi Naor^a ; ² ; ^{zvin@tauex.tau.ac.il}
• 关键词：GnRH ; PKCα ; PKCβII ; PKCδ ; PKCε ; MAPKs ; p38 ; Gonadotropes ; αT3-1 and LβT2 cells
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：141-154
• 全文大小：3566 K
• 卷排序：439

文摘

GnRH and PMA stimulate p38MAPK phosphorylation in αT3-1 and LβT2 gonadotrope cells. Selective PKCs play a role in p38MAPK phosphorylation in a ligand-and cell context-dependent manner. Different Ca2 pools play a role in p38MAPK phosphorylation in αT3-1 vs. LβT2 cells.